Global Breakthrough: FGC2.3 Feline Vocalization Project Nears Record Reads — Over 14,000 Scientists Engage With Cat-Human Translation Research

Global Breakthrough: FGC2.3 Feline Vocalization Project Nears Record Reads — Over 14,000 Scientists Engage With Cat-Human Translation Research

MIAMI, FL — The FGC2.3: Feline Vocalization Classification and Cat Translation Project, authored by Dr. Vladislav Reznikov, has crossed a critical scientific milestone — surpassing 14,000 reads on ResearchGate and rapidly climbing toward record-setting levels in the field of animal communication and artificial intelligence. This pioneering work aims to develop the world’s first scientifically grounded…

Tariff-Free Relocation to the US

Tariff-Free Relocation to the US

EU, China, and more are now in the crosshairs. How’s next? It’s time to act. The Trump administration has announced sweeping tariff hikes, as high as 50%, on imports from the European Union, China, and other major markets. Affected industries? Pharmaceuticals, Biotech, Medical Devices, IVD, and Food Supplements — core sectors now facing crippling costs,…

Global Distribution of the NRAs Maturity Levels as of the WHO Global Benchmarking Tool and the ICH data

Global Distribution of the NRAs Maturity Levels as of the WHO Global Benchmarking Tool and the ICH data

This study presents the GDP Matrix by Dr. Vlad Reznikov, a bubble chart designed to clarify the complex relationships between GDP, PPP, and population data by categorizing countries into four quadrants—ROCKSTARS, HONEYBEES, MAVERICKS, and UNDERDOGS depending on National Regulatory Authorities (NRAs) Maturity Level (ML) of the regulatory affairs requirements for healthcare products. Find more details…

Prasad Makes a Comeback, Delany Exits, Lilly’s Weight Loss Product Fails to Impress, and Ongoing Issues for Sarepta

Prasad Makes a Comeback, Delany Exits, Lilly’s Weight Loss Product Fails to Impress, and Ongoing Issues for Sarepta

CBER Chief Vinay Prasad reclaimed his job less than two weeks after his mysterious exit; MAHA implementor Gray Delany is out after reportedly sparring with other agency officials over communications strategy; Eli Lilly’s first Phase III readout for oral obesity drug orforglipron missed analyst expectations; and Arrowhead Pharmaceuticals addresses the recent woes of its of partner Sarepta.

Meta’s Innovative Bracelet Interprets Hand Movements

Meta’s Innovative Bracelet Interprets Hand Movements

Imagine the ability to control machines with your mind, instead of having to type on a keyboard or click on a mouse. Now Facebook’s parent company Meta is aiming for the next best thing—a new wristband that can, with the help of AI, infer electrical commands sent from the brain to muscles and convert them into computer signals, all in a noninvasive way. Although experts doubt it will replace keyboards and mice for traditional computing, it might have new uses for a wide range of applications, such as wearable interfaces for mobile devices, or thought-controlled assistive technologies for people with disabilities.

The bracelet from Reality Labs at Meta uses metal contacts placed against the skin to detect electrical signals from muscles—a technique known as surface electromyography (sEMG)—which are generated in response to commands from the brain. The highly sensitive new system transmits this data to a computer using Bluetooth to help it recognize gestures such as pointing and pinching in real time, findings detailed in Nature on 23 July.

The bracelet is not a direct interface with the brain. “It is not a mind-reading system. It cannot make you act in a different way as imposed by your will, it does not connect you to other people neurally, it does not predict your intentions,” says Dario Farina, chair in neurorehabilitation engineering at Imperial College, London, who did not take part in Meta’s research but has tested the technology. (Meta was unable to make anyone available for comment as of press time.)

How AI Enables Meta’s Wristband

Previous “neuromotor” devices, such as the discontinued Myo armband, also sought to use sEMG for computer interfaces. A key challenge these earlier devices faced was how they each needed time-consuming personalized calibration for each user to account for differences in human anatomy and behavior.

See how the device detects thumb swipes, finger taps, and handwriting gestures.Reality Labs at Meta

In contrast, Meta says its bracelet can essentially work off-the-shelf. The key was training deep learning artificial intelligence systems on data from more than 6,000 paid volunteers who wore the device. This generated models that could accurately interpret user input across different people without requiring individual calibration, says Joe Paradiso, head of the Responsive Environments Research Group at the MIT Media Lab, who did not participate in this study.

“The amount of information decoded with this device is very large, far larger than any previous attempt,” Farina says. “The device can recognize handwriting, for example, which would have not been conceivable before.”

An illustration imagines surface electromyography (SEMG) signals working through the hand The wristband uses surface electromyography to non-invasively measure electrical activity of the muscles that control hand gestures.Reality Labs at Meta

A possible concern with using this wristband is how users might not want every hand motion interpreted as input—say, if they had to scratch an itch, or pick up a glass of water. However, the device is trained to recognize only certain commands, while ignoring other gestures. “A potential user of the device can perform any activity of daily living without the risk to activate the device, and yet control the device with the specific gestures for which the device has been trained,” Farina says.

In tests, volunteers who had never previously tried the bracelet could use handwriting gestures to input text at 20.9 words per minute. (In comparison, mobile phone keyboard typing speeds average roughly 36 words per minute.)

Given this interface speed, “I doubt most computer users would rush out to buy this wristband if it becomes commercially available,” says Eben Kirksey, a professor of anthropology at the University of Oxford who studies the interplay of science, technology, and society. “Most people type at around 40 words a minute and highly skilled typists can bang out upwards of 100 words a minute. Since this new wearable device only enables users to write 20 words a minute, I doubt many people will want to take the time to learn how to use this new way to interface with computers.”

Instead, the new study argues the bracelet might prove useful in scenarios where keyboards or mice would be limiting, such as mobile and wearable applications. “It’s not a keyboard replacement. It’s something else, and I think things like this are needed for the computational paradigms that are coming,” Paradiso says.

For example, when it comes to the virtual reality and augmented reality glasses that Meta, Google, and others have pursued, interfaces previously envisioned for these devices include vision-based trackers that track the motions of hands held up in front of users, Paradiso says. However, the fatigue that can set in with this “gorilla arm” approach limits long-term use, and “the need to use space in front of you has its drawbacks,” Paradiso notes.

Because this new bracelet interprets electrical signals instead of motion, it could instead let users keep their hands to their sides and interact with devices using subtle finger motions. “Interfaces like these are needed for the everywhere-computing eyewear that’s emerging,” Paradiso says. “My favorite scenario is on a crowded train with my head-worn display catching up with the news, or communicating with friends. You just nudge it around with your hands by your side. Going for a walk, and so on—same deal.”

Applications for Accessibility

The researchers also suggest the wristband could help people with disabilities better interact with computers, particularly individuals with reduced mobility, muscle weakness, finger amputations, paralysis and more. “Some members of the disabled community have difficulty typing on conventional keyboards, or using computer mice,” says Kirksey, who did not take part in this research. “This device offers a new option that might help some members of this community, who have very specific bodily challenges, interface with computers.”

For such applications, a virtue of the new bracelet is that it is relatively easy to don and doff. In contrast, brain-computer interfaces (BCIs), which also rely on electrical signals from the brain, often require invasive brain surgery. Non-invasive BCIs do exist, such as ones that apply electrodes onto the scalp, “but a wristband is more ergonomic than a skullcap,” Paradiso says.

However, many questions remain before this new technology might help people with disabilities. “This type of wearable assumes typical limb shape and fine motor control,” says Solomon Romney, formerly the head of Microsoft’s Inclusive Design Lab. “As a limb-different person, I am always looking for ways to move activities to my limblet rather than continue to overload my typical hand. How easily can it be adjusted to fit non-typical limbs and-or musculature? How does it filter tremors? How effectively would it work for someone with no hands to wear on their ankle?”

Ultimately, “the main obstacle is large-scale deployment,” Farina says. “To be distributed to millions of individuals, the system needs to be robust across different anatomies and be used with minimal error rate. To match the error rate of a mouse or keyboard in a vast human population is certainly a huge challenge.”

Kava Removed from the Menu in New York City

Kava Removed from the Menu in New York City

Restaurants in New York City can no longer serve kava drinks, thanks to a recent ruling on steeped kava beverages. A federal judge recently ruled in favor of New York City public health and safety officials who shut down two Kavasutra locations for serving kava tea.

Arrowhead Emerges as the RNAi Hero Amidst the Sarepta ‘Downdraft’

Arrowhead Emerges as the RNAi Hero Amidst the Sarepta ‘Downdraft’

Sarepta’s troubles had nothing to do with Arrowhead’s assets, and yet both companies have seen their stock prices decline this past month. BioSpace caught up with Arrowhead’s Chris Anzalone to talk about the biotech’s role as an RNAi pipeline savior.

Streamlined DNA Mutation Detection Through “Electrical Genotyping”

Streamlined DNA Mutation Detection Through “Electrical Genotyping”

A new microfluidic chip simplifies detecting and quantifying DNA by analyzing electrical impedance signals that vary based on DNA flowing across a biosensor inside the chip. The proof-of-concept technique, called electrical genotyping, can accurately detect single-point mutations faster and more simply than traditional genotyping, which typically takes days or weeks and can be prohibitively expensive.

The new tool, developed by scientists at Rutgers University and Yale University, won’t replace all genotyping, but it could still be a powerful, yet affordable, screening tool that one day expands the ability of any clinic’s early detection of rare diseases. “What we’re trying to make is the equivalent of a glucose meter, but for detecting genetic mutations,” says Mehdi Javanmard, a professor in the Rutgers electrical and computer engineering department.

Detecting Hereditary Genetic Mutations

The researchers focused on detecting a hereditary single mutation that causes transthyretin cardiac amyloidosis, a disease that can lead to congestive heart failure. It is underdiagnosed and disproportionately affects people with West African ancestry.

The researchers ran clinical samples of six patients, four of whom had the mutation, through the tool. The initial sample preparation steps amplified the mutated section of DNA. When the four samples with amplified amounts of DNA containing the relevant mutation were run, the biosensor correctly detected the DNA through changes in electrical impedance. It also measured low concentrations of DNA in nonamplified samples lacking the mutation. Javanmard and his colleagues published their findings in June in Nature Communications Engineering.

In general, electrochemical biosensors have advanced research for various applications, including detecting cancer biomarkers, and DNA data storage and synthesis. This study’s detection is done with label-free impedance biosensors. (Labels are like attaching baggage tags to DNA. They are commonly used for accurate detection, but require extra steps that cost time and money.) “The novelty of the sensing component is being able with high sensitivity to detect DNA without any fluorescent tags” or other labels, Javanmard says.

“Instead of 15 steps and a 5-hour-long run with a DNA sequencer, we’re talking about something that’s significantly shorter, a couple of steps on the sample-preparation side and then just one step on the detection side. Within 5 minutes, the detection is performed,” says Javanmard. The simplified sample preparation was developed by Curt Scharfe, a professor of genetics at Yale, and his lab.

DNA Detection Through Electrical Impedance

Before DNA can be detected, it must be prepared using the targeted technique developed by Scharfe’s team. “It’s the amplification process that allows you to differentiate between the wild type [nonmutated] and the mutation,” says Javanmard.

Then the amplified DNA solution, driven by passive capillary flow, washes through the microfluidic channel of the biosensor and across submerged gold electrodes. The channel and the gold electrodes form a sensing circuit. The solution in the channel is modeled as a resistor and the DNA is modeled as a dipole capacitance due to its negatively charged properties and inherent conductivity.

Essentially, the method measures conductivity. The electrical conductivity of a solution containing DNA is different than a solution without it, so the signal can be differentiated.

An external impedance spectroscope sends a low-frequency stimulus (between 10 and 250 kilohertz) to the circuit, generating an electrical field. As the DNA solution flows through the channel, it changes the electrical conductivity, and thus the impedance in the sensing circuit. This rate of impedance change is measured by the sensor as a raw current signal.

That signal is fed into off-chip equipment. First it goes into a transimpedance amplifier that boosts the signal to a more detectable level and converts it into a voltage. Then it enters a lock-in amplifier, which reduces noise and outputs a clear signal by extracting, digitizing, and filtering the input. Finally, the data is analyzed.

As the DNA concentration in the sensing region increases, the rate of change of the output voltage increases too, and the system measures the amount of DNA present. This is what the researchers dub a “DNA quantification score.” To improve the score’s accuracy, they average the readouts from four low-frequency signals sent to the circuit.

For both nonmutated and mutated samples, the gold standard biological readout is “fluorescence intensity correlated with the electrical DNA quantification score,” notes Javanmard. Their simpler electrical-detection technique could replace the more manual biological readout and be more portable in resource-constrained settings.

The label-free technique itself is not new, but “there’s no one-size-fits-all electrical impedance sensor,” says Javanmard. He also says it’s a combination of how the measurement was performed, selecting the right mix of excitation frequencies for impedance, and postmeasurement data analytics that makes their sensor optimized and novel.

To get beyond a proof of concept, the chip’s sensitivity to detect DNA will still need to be improved. The study authors believe one approach is to reduce the sensing area, which creates a greater threshold difference between a DNA impedance signal and a no-DNA signal.

They would also need to bring the electronics and biological amplification on-chip. Javanmard said they’ve already shown that it’s possible to miniaturize the off-chip electronics in a device made by RizLab Health, a company spun off from his lab.

This technique could also have applications beyond medical diagnostics. Javanmard notes, “as DNA storage becomes more and more advanced, there will be a need for technologies for accurate readout and error control. Rapid and advanced DNA biosensors will become a necessity.”

Commemorating 25 Years of Innovative Oral Microbiome Research: The Journey of NZ’s BLIS Technologies

Commemorating 25 Years of Innovative Oral Microbiome Research: The Journey of NZ’s BLIS Technologies

BLIS Technologies, founded on the pioneering research of Professor John Tagg, has been at the forefront of oral microbiome science for 25 years, with a focus on developing probiotics like BLIS K12 and BLIS M18 to combat oral pathogens and enhance immune health. Dr. John Hale, a key figure in the company, highlights the success of BLIS K12 in reducing throat infections and its potential in sports nutrition, while BLIS M18 targets dental health by reducing plaque and gum disease. The company continues to innovate, expanding its probiotic repertoire beyond the oral cavity to include skin health, while maintaining its commitment to oral health research.